CD62P (P-Selectin) Monoclonal Antibody (AK4), Biotin
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA528596 | 100 µg | 236,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The antibody AK4 recognizes CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma membrane upon activation. P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and t
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, IP, WB |
Regulatory Status | RUO |
Immunogen | Human platelets |
Host | Ms |
Clone Number | [AK4] |
Genebank | SELP |
Isotype | IgG1,k |
Crossreactivity | Chimpanzee, Hu |
Clonality | Mab |
Format | liquid; PBS; pH 7.4, with 15mM sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Flow Cytometry (1-2 µg/mL), Western Blot (Assay-dependent), Immunocytochemistry (Assay-dependent)... |
Purity | Size-exclusion chromatography |
Conjugation | Biotin |
Storage Conditions | 4° C, do not freeze |
Disclaimer | Alternative CatNo: MA5-28596 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |