CD43 Monoclonal Antibody (MEM-59), Alexa Fluor™ 700
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA528597 | 100 Tests | 348,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The antibody MEM-59 recognizes neuraminidase-sensitive epitope on CD43 (Leukosialin), a 95-135 kDa type I transmembrane glycoprotein (mucin-type) which is involved in lymphocyte activation. CD43 is expressed by platelets and at high levels on the surface of all leukocytes; it is negative on resting B lymphocytes and erythrocytes. Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension. CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction includ
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Human T lymphocytes. |
Host | Ms |
Clone Number | [MEM-59] |
Genebank | SPN |
Isotype | IgG1 |
Crossreactivity | Hu |
Clonality | Mab |
Format | liquid; TBS; pH 8, with 0.2% BSA and 15mM sodium azide |
Working Dilution | Flow Cytometry (4 µL/1x10^6 cells) |
Purity | Size-exclusion chromatography |
Conjugation | Alexa Fluor 700 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-28597 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |