CD71 (Transferrin Receptor) Monoclonal Antibody (MEM-75), Alexa Fluor™ 700
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA528599 | 100 Tests | 348,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | NALM-6 human pre-B cell line |
Host | Ms |
Clone Number | [MEM-75] |
Genebank | TFRC |
Isotype | IgG1 |
Crossreactivity | Hu |
Clonality | Mab |
Format | liquid; PBS; pH 7.4, with 0.2% BSA and 15mM sodium azide |
Working Dilution | Flow Cytometry (4 µL/1x10^6 cells) |
Purity | Size-exclusion chromatography |
Conjugation | Alexa Fluor 700 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-28599 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |