CD8 alpha Monoclonal Antibody (CT-8), Cyanine5
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA528722 | 1 mL | 464,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Chicken thymocytes and Ig-negative blood leukocytes |
Host | Ms |
Clone Number | [CT-8] |
Genebank | CD8A |
Isotype | IgG1,k |
Crossreactivity | Avian, Ck |
Clonality | Mab |
Format | Liquid; PBS; , with sucrose and <0.1% sodium azide |
Concentration | 0.1 mg/mL |
Working Dilution | Flow Cytometry (0.2 µg/10^6 cells) |
Purity | purified |
Conjugation | Cy5 |
Storage Conditions | 4° C, store in dark |
Disclaimer | Alternative CatNo: MA5-28722 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |