5-Methylcytosine Monoclonal Antibody (GT4111)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA531475 | 100 µL | 686,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Keep as concentrated solution. Positive Control: SH-SY5Y genomic DNA. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | DB, IHC, IP |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | The immunogen used to generate this antibody corresponds to 5-Methylcytosine/5-mC. |
| Host | Ms |
| Clone Number | [GT4111] |
| Isotype | IgG1 |
| Crossreactivity | Chemical |
| Clonality | Mab |
| Format | Liquid; PBS; , with no preservative |
| Concentration | 1.7 mg/mL |
| Working Dilution | Dot Blot (Assay-dependent), Immunohistochemistry (Paraffin) (1:100-1:1,000), Immunohistochemistry... |
| Purity | Protein G |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: MA5-31475 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
