14-3-3 beta Monoclonal Antibody (9-26)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA532862 | 100 µL | 604,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms(beta, gamma, epsilon, eta, zeta, sigma and tau/theta) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Recombinant protein within Human 14-3-3 b/a aa 1-246 |
| Host | Ms |
| Clone Number | [9-26] |
| Genebank | YWHAB |
| Isotype | IgG2a |
| Crossreactivity | Hu, Ms, Rt, Zebrafish |
| Clonality | Mab |
| Format | Liquid; PBS; pH 7.4, with 0.2% BSA, 40% Glycerol and 0.05% sodium azide |
| Concentration | 2 mg/mL |
| Working Dilution | Western Blot (1:1,000-1:2,000), Immunocytochemistry (1:100), Immunohistochemistry (1:200) |
| Purity | Protein A |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: MA5-32862 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
