C1QBP Monoclonal Antibody (60.11)

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Product Description

Product is supplied at 1 mL (100 µL/mL). This antibody is directed against epitopes situated within the NH2-terminal stretch of gC1q-R corresponding to residues 76-93. This antibody recognizes the putative C1q binding site and reacts with the mature form, but has poor or no reactivity with the truncated form, lacking residues 74- 95. In ELISA applications, this antibody can be used as the capture or detection antibody. Replication Protein A (RPA) (also known as human single-stranded DNA binding protein, or HSSB) is involved in DNA replication, repair, and recombination. RPA from human cells is a stable heterotrimer of 70kDa, 32-34kDa, and 11-14kDa subunits (RPA70, RPA32, and RPA14 respectively). RPA is required for the SV40 large tumor antigen-catalyzed unwinding of SV40 DNA and stimulates DNA polymerase alpha and delta. RPA34 is phosphorylated at the G1/S boundary of the cell cycle or upon exposure of cells to DNA damage-inducing agents including ionizing and UV radiation.