Phospho-MSK1 (Thr581) Recombinant Rabbit Monoclonal Antibody (MSK1T581-A5), FITC
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA536890 | 10 Tests | 198,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ab
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Thr581 of human phospho MSK1. |
Host | Rb |
Clone Number | [MSK1T581-A5] |
Genebank | RPS6KA5 |
Isotype | IgG,k |
Crossreactivity | Hu, Ms |
Clonality | Recombi |
Format | Liquid; PBS; , with 0.20% BSA and 0.09% sodium azide |
Working Dilution | Flow Cytometry (5 µL/1x10^6 cells) |
Purity | Protein A/G |
Conjugation | FITC |
Storage Conditions | 4° C, store in dark |
Disclaimer | Alternative CatNo: MA5-36890 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |