Phospho-Jak1 (Tyr1022, Tyr1023) Recombinant Rabbit Monoclonal Antibody (Jak1Y10221023-F11), FITC
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA536892 | 10 Tests | 198,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1022/1023 of human phospho-Jak1. |
Host | Rb |
Clone Number | [Jak1Y10221023-F11] |
Genebank | JAK1 |
Isotype | IgG,k |
Crossreactivity | Hu |
Clonality | Recombi |
Format | Liquid; PBS; , with 0.20% BSA and 0.09% sodium azide |
Working Dilution | Flow Cytometry (5 µL/1x10^6 cells) |
Purity | Protein A/G |
Conjugation | FITC |
Storage Conditions | 4° C, store in dark |
Disclaimer | Alternative CatNo: MA5-36892 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |