PCAF Monoclonal Antibody (7D12C8)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA538547 | 100 µg | 564,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody has been tested in indirect ELISA. PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, FC, ICC, IHC, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Purified recombinant fragment of human KAT2B (aa: 1-142) expressed in E. Coli. |
| Host | Ms |
| Clone Number | [7D12C8] |
| Genebank | KAT2B |
| Isotype | IgG1 |
| Crossreactivity | Hu, Ms, Primate, Rt |
| Clonality | Mab |
| Format | Liquid; PBS; , with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Flow Cytometry (1:200-1:400), Immunocytochemistry (1:200-1:1,000), Immunohistochemistry (Paraffin... |
| Purity | Protein G |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: MA5-38547 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
