CD3 Monoclonal Antibody (UCHT1), APC-Cyanine7
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA538705 | 100 Tests | 361,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Do not use after expiration date stamped on vial label. The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | human thymocytes followed by Sezary T cells |
Host | Ms |
Clone Number | [UCHT1] |
Genebank | CD247 |
Isotype | IgG1 |
Crossreactivity | Hu, Primate |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 15mM sodium azide |
Working Dilution | Flow Cytometry (4 µL/1x10^6 cells) |
Purity | Size-exclusion chromatography |
Conjugation | APC/Cy7 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-38705 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |