HLA-DR Monoclonal Antibody (L243), PE-Cyanine5
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA538756 | 100 Tests | 337,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Do not use after expiration date stamped on vial label. HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Human B lymphocytes |
Host | Ms |
Clone Number | [L243] |
Genebank | CD74 |
Isotype | IgG2a,k |
Crossreactivity | Dg, Hu, Primate |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 15mM sodium azide |
Concentration | 55 µg/mL |
Working Dilution | Flow Cytometry (4 µL/1x10^6 cells) |
Purity | Size-exclusion chromatography |
Conjugation | PE/Cy5 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-38756 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |