5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody (GT513)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA542319 | 100 µL | 464,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. 5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.
Category | Antibody |
Supplier | ThermoFisher |
Application | DB, IP |
Regulatory Status | RUO |
Immunogen | The immunogen used to generate this antibody corresponds to 5-Hydroxymethylcytosine / 5-hmC |
Host | Ms |
Clone Number | [GT513] |
Isotype | IgG2b |
Crossreactivity | Chemical |
Clonality | Mab |
Format | Liquid; PBS; , with no preservative |
Concentration | 1 mg/mL |
Working Dilution | Dot Blot (Assay-dependent), Methylated DNA Immunoprecipitation (1:500) |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA5-42319 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |