CDK4 Monoclonal Antibody (5-C3-G3)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA542575 | 100 µL | 487,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Positive Control: Hela, human breast tissue, human stomach cancer tissue. Subcellular Location: Cytoplasm. Nucleus. Membrane. CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of the gene have been reported.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Recombinant protein within human cdk4 aa 80-303 |
| Host | Ms |
| Clone Number | [5-C3-G3] |
| Genebank | CDK4 |
| Isotype | IgG2c |
| Crossreactivity | Hu |
| Clonality | Mab |
| Format | Liquid; PBS; pH 7.4, with 0.2% BSA, 40% glycerol and 0.05% sodium azide |
| Concentration | 2 mg/mL |
| Working Dilution | Immunohistochemistry (Paraffin) (1:50-1:200), Western Blot (1:500-1:1,000) |
| Purity | Protein A |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: MA5-42575 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
