Ki-67 Monoclonal Antibody (Ki-67), Alexa Fluor™ 647
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA544140 | 100 Tests | 438,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, WB |
Regulatory Status | RUO |
Immunogen | Nuclei of the Hodgkin lymphoma cell line L428 |
Host | Ms |
Clone Number | [Ki-67] |
Genebank | MKI67 |
Isotype | IgG1 |
Crossreactivity | Bo, Hu |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 15mM sodium azide |
Working Dilution | Flow Cytometry (4 µL/1x10^6 cells), Immunocytochemistry (Assay-dependent), Western Blot (Assay-de... |
Purity | Size-exclusion chromatography |
Conjugation | Alexa Fluor 647 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA5-44140 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |