5-Carboxylcytosine Recombinant Rabbit Monoclonal Antibody (RM462)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA544548 | 50 µg | 502,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody reacts to human NeuN (Fox3, RBFOX3). The clone may also react to mouse or rat NeuN, as predicted by immunogen homology. 5-carboxylcytosine is the final oxidized derivative of 5-methylcytosine, a type of DNA methylation. 5-methylcytosine is oxidized to 5-hydroxymethylcytosine which is then oxidized to 5-formylcytosine and later to 5-carboxylcytosine. These oxidations are catalyzed by the Ten-Eleven Translocation (TET) enzyme family. 5-carboxylcytosine has been shown to cause reduced fidelity of RNA Polymerase II. Decreased levels of 5-hydroxymethylcytosine has been found in some cancers.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | DB, EL |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | KLH-conjugated 5-Carboxylcytosine. |
| Host | Rb |
| Clone Number | [RM462] |
| Isotype | IgG |
| Crossreactivity | Chemical |
| Clonality | Recombi |
| Format | Liquid; PBS; , with 1% BSA, 50% glycerol and 0.09% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Dot Blot (100-1,000 ng/mL), ELISA (200-2,000 ng/mL) |
| Purity | Protein A |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: MA5-44548 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
