p23 Monoclonal Antibody (JJ6), APC
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA545195 | 100 µg | 376,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Recombinant human full length p23 protein |
Host | Ms |
Clone Number | [JJ6] |
Genebank | PTGES3 |
Isotype | IgG1 |
Crossreactivity | Ck, Gp, Hu, Ms, Rb, Yeast |
Clonality | Mab |
Format | Liquid; 2.15mM MES, 47.35mM phosphate; pH 7.4, with 1.033mM EDTA and no preservative |
Concentration | 1 mg/mL |
Working Dilution | ELISA (Assay-dependent), Immunocytochemistry (1:100), Immunohistochemistry (Paraffin) (1:100), Im... |
Purity | Protein G |
Conjugation | APC |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: MA5-45195 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |