CRYAB Monoclonal Antibody (1A7.D5), PerCP
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA545200 | 200 µg | 415,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, ICC, WB |
Regulatory Status | RUO |
Immunogen | Native Alpha B Crystallin |
Host | Ms |
Clone Number | [1A7.D5] |
Genebank | CRYAB |
Isotype | IgG1 |
Crossreactivity | Bo, Hu, Pg, Rt |
Clonality | Mab |
Format | Liquid; 2.15mM MES, 47.35mM phosphate; pH 7.2, with 1.033mM EDTA and no preservative |
Concentration | 1 mg/mL |
Working Dilution | ELISA (Assay-dependent), Immunocytochemistry (1:100), Western Blot (1:2,000) |
Purity | Protein G |
Conjugation | PerCP |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: MA5-45200 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |