c-Fos Monoclonal Antibody (4A3), APC
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA545883 | 100 µg | 406,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Synthetic peptide from the N-terminal of Human c-Fos (aa. 280-380) |
| Host | Ms |
| Clone Number | [4A3] |
| Genebank | FOS |
| Isotype | IgG2 |
| Crossreactivity | Hu, Rt |
| Clonality | Mab |
| Format | Liquid; 2.15mM MES, 47.35mM phosphate; pH 7.4, with 1.033mM EDTA and no preservative |
| Concentration | 1 mg/mL |
| Working Dilution | Immunohistochemistry (1:100), Western Blot (1:1,000) |
| Purity | Protein G |
| Conjugation | APC |
| Storage Conditions | 4° C |
| Disclaimer | Alternative CatNo: MA5-45883 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
