GAD65 Monoclonal Antibody (HL1187)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA546952 | 100 µL | 406,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Store as concentrated solution. Centrifuge briefly prior to opening vial. GAD65 (glutamic acid decarboxylase-65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human GAD65. The exact sequence is proprietary. |
| Host | Rb |
| Clone Number | [HL1187] |
| Genebank | GAD2 |
| Isotype | IgG |
| Crossreactivity | Dg, Ca, Hu, Ms, Rt, Zebrafish |
| Clonality | Mab |
| Format | Liquid; PBS; , with no preservative |
| Concentration | 1 mg/mL |
| Working Dilution | Immunocytochemistry (Assay-dependent), Immunohistochemistry (Paraffin) (Assay-dependent), Western... |
| Purity | Protein A |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: MA5-46952 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
