HGS Recombinant Rabbit Monoclonal Antibody (HL1730)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA547159 | 100 μL | 464,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Store as concentrated solution. Centrifuge briefly prior to opening vial. HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ICC, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human HGS. The exact sequence is proprietary. |
| Host | Rb |
| Clone Number | [HL1730] |
| Genebank | HGS |
| Isotype | IgG |
| Crossreactivity | Dg, Ca, Hu |
| Clonality | Mab |
| Format | Liquid; PBS; , with no preservative |
| Concentration | 2 mg/mL |
| Working Dilution | Immunocytochemistry (Assay-dependent), Western Blot (1:500-1:3,000) |
| Purity | Protein A |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: MA5-47159 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
