CD56 Monoclonal Antibody (MEM-188), PE-Texas Red
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MHCD5617 | 500 µL | 736,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The R-phycoerythrin (PE)-Texas Red conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser. This antibody recognizes an isoform of neural cell adhesion molecule (NCAM) also known as NKH-1. CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa. CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. Polysialic modification results in reduction of CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins. CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma. Further, CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendrit
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Human CD56 |
Host | Ms |
Clone Number | [MEM-188] |
Genebank | NCAM1 |
Isotype | IgG2a,k |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; , with BSA, sucrose and 0.1% sodium azide |
Working Dilution | Flow Cytometry (Assay-Dependent) |
Purity | purified |
Conjugation | PE/Texas Red |
Storage Conditions | 4° C, store in dark |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |