Zap-70 Monoclonal Antibody (1E7.2), Pacific Blue™
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MHZAP7028 | 500 µL | 466,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Our Pacific Blue™ dye is optimally excited by the violet laser and conjugates of this dye are strongly fluorescent even at neutral pH. Pacific Blue™ and Pacific Orange™ dye conjugates can be simultaneously excited at 405 nm and emit at 455 nm and 551 nm, respectively, facilitating two-color analysis. ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | GST-fusion protein of Human ZAP70, amino acids 282-307 |
Host | Ms |
Clone Number | [1E7.2] |
Genebank | ZAP70 |
Isotype | IgG1 |
Crossreactivity | Hu, Ms |
Clonality | Mab |
Format | Liquid; PBS; , with 4mg/mL BSA and 0.1% sodium azide |
Working Dilution | Flow Cytometry (Assay-Dependent) |
Purity | Affinity chromatography |
Conjugation | Pacific Blue |
Storage Conditions | 4° C, store in dark |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |