Apolipoprotein B Monoclonal Antibody (F2C3)

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Product Description

MIA1605 targets Apolipoprotein B in ELISA, IP, and RIA applications and shows reactivity with Human samples. The MIA1605 immunogen is purified human serum LDL. MIA1605 detects Apolipoprotein B which has a predicted molecular weight of approximately 513 kDa. MIA1605 was formerly sold as a Seradyn product. Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearance of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. MDA-oxidized LDL appear to be different from LDL oxidized by other means. Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low