CRP Monoclonal Antibody (P4D7)

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Product Description

MIC0501 targets C Reactive Protein in ELISA, IP, and RIA applications and shows reactivity with Human samples. The MIC0501 immunogen is purified human plasma CRP. MIC0501 detects C Reactive Protein which has a predicted molecular weight of approximately 23 kDa. MIC0501 was formerly sold as a Seradyn product. CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits. Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa. CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance. Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation. CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell ne