Fibronectin Monoclonal Antibody (3F12)

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Product Description

MIF2601 has been successfully used in WB, ELISA, immunofluorescence, immunoprecipitation, and radioimmune assay applications, and reacts with human samples. MIF2601 detects Fibronectin which has a predicted molecular weight of approximately 259 kDa. MIF2601 was formerly sold as a Seradyn product. Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fi