NF-H Monoclonal Antibody (RNF 404)

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Product Description

OMA1-06115 specifically detects the phosphorylated 200 kDa neurofilament from Human, Bovine, Canine, Chicken, Guinea Pig, Non-human primate, mouse, Rabbit, Rat, Ovine and Xenopus tissues. OMA1-06115 has been successfully used in Western blot, IHC (F), and IHC (P) procedures. By Western blot, this antibody detects an ~200 kDa protein representing the phosphorylated form of the 200 kDa neurofilament from human brain homogenate. OMA1-06115 antigen is cytoskeletal preparation of calf brain tissue. Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-H has an important role in mature axons and is involved in amyotrophic lateral sclerosis (ALS).