KDEL Polyclonal Antibody, Alexa Fluor™ 488
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA1013A488 | 50 µL | 638,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
PA1013A488 detects KDEL from human, rat, mouse and hamster. The PA1013A488 immunogen is a synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP94. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins, GRP78 and GRP94 respectively, and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ICC |
| Regulatory Status | RUO |
| Immunogen | Synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP94 |
| Host | Rb |
| Genebank | HSP90B1 |
| Isotype | IgG |
| Crossreactivity | Hm, Hu, Ms, Rt |
| Clonality | Pab |
| Format | Liquid; PBS; pH 7.4, with 1mg/mL BSA and 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Immunocytochemistry (1-10 µg/mL) |
| Purity | Antigen affinity chromatography |
| Conjugation | Alexa Fluor 488 |
| Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
| Disclaimer | Alternative CatNo: PA1-013-A488 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
