NF-H Polyclonal Antibody

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Product Description

PA1-10016 detects Neurofilament NF-H, primarily the hyperphosphorylated axonal form which yields a band at ~200kDa in Western blot applications. Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-H has an important role in mature axons and is involved in amyotrophic lateral sclerosis (ALS).