PPP6C Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA112400 | 100 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5' to 3' exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5' and 3' overhang processing in nonhomologous DNA end joining.
Category | Antibody |
Supplier | ThermoFisher |
Application | IP, WB |
Regulatory Status | RUO |
Immunogen | Synthetic peptide. |
Host | Sh |
Genebank | PPP6C |
Isotype | IgG |
Crossreactivity | Bo, Hu, Ms, Rt |
Clonality | Pab |
Format | Liquid; PBS; , with 0.08% sodium azide |
Working Dilution | Immunoprecipitation (Assay-dependent), Western Blot (Assay-dependent) |
Purity | Ammonium sulfate precipitation |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PA1-12400 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |