TGF beta-3 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA112642 | 250 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
A suggested positive control for this product is extraembryonic membranes from chick embryos. Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Recombinant protein corresponding to the extracellular domain of the chicken TGF III receptor. |
Host | Sh |
Genebank | TGFB3 |
Isotype | IgG |
Crossreactivity | Ck |
Clonality | Pab |
Format | Liquid; PBS; , with 0.08% sodium azide |
Working Dilution | Western Blot (Assay-dependent), Immunohistochemistry (Assay-dependent), Immunocytochemistry (Assa... |
Purity | Ammonium sulfate precipitation |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PA1-12642 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |