GPR68 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA112713 | 100 µg | 732,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Western blot should be visualized using a high sensitivity secondary/substrate system (i.e SuperSignal West Femto Maximum Sensitivity Substrate). A suggested positive control for this product is OGR1 transfected cell lysate. GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | IHC, N, WB |
| Regulatory Status | RUO |
| Immunogen | Recombinant protein corresponding to human OGR1 (GPR68) protein. |
| Host | Rb |
| Genebank | GPR68 |
| Isotype | IgG |
| Crossreactivity | Hu |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.08% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Neutralization (Assay-dependent), Western Blot (5-10 µg/mL), Immunohistochemistry (Assay-dependent) |
| Purity | Protein A/G |
| Conjugation | Unconjugated |
| Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
| Disclaimer | Alternative CatNo: PA1-12713 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
