APE1 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA116500 | 100 µL | 538,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
In IHC applications, this antibody can be competitively inhibited from recognizing the APE1 antigen in tissues using APE1 protein. This antibody can be used on frozen sections, fixed-paraffin sections and cytospin preps. Suggested positive control: Hela whole cell extract, antigen standard for APEX1 (transient overexpression lysate). Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases. APE is differentially expressed during development and in different tissues. This protein has diverse subcellular localization patterns which support the possibility of its interaction with numerous, other cellular protei
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, FC, ICC, IHC, IP, N, WB |
Regulatory Status | RUO |
Immunogen | Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein |
Host | Rb |
Genebank | APEX1 |
Isotype | IgG |
Crossreactivity | Hu, Ms, Primate, Rb, Rt |
Clonality | Pab |
Format | Liquid; PBS; , with 0.02% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Flow Cytometry (Assay-Dependent), Immunocytochemistry (1:50-1:200), Immunoprecipitation (7 µg/mL)... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PA1-16500 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |