53BP1 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA116566 | 100 µL | 596,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Human samples have been tested in Western Blot and ICC/IF, and mouse samples have been tested in ICC/IF only. Suggested positive control: U205, 293T, and MO59K cell lysates and MEF lysates . 53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ChIP, FC, ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Synthetic peptide of human tumor protein p53 binding protein 1 region encoded exon 19 (LocusLink ID 7158) |
| Host | Rb |
| Genebank | TP53BP1 |
| Isotype | IgG |
| Crossreactivity | Bat, Bo, Dg, Hu, Ms, Rt, Rodent |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.02% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Flow Cytometry (2-5 µg/million cells), Immunocytochemistry (1:50-1:1,000), Immunohistochemistry (... |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: PA1-16566 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
