CYR61 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA116579 | 100 µL | 660,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody is predicted to react with rat and mouse based on 88% sequence homology. Suggested positive control: antigen standard for CYR61 (transient overexpression lysate), MDA-MB-231 breast cancer cell lysate. CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ICC, IHC, N, WB |
| Regulatory Status | RUO |
| Immunogen | A synthetic peptide made to the human CYR61 protein sequence (between residues 150-250). |
| Host | Rb |
| Genebank | CCN1 |
| Isotype | IgG |
| Crossreactivity | Hu, Ms, Rb |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.02% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Neutralization (50-200 molar excess), Western Blot (1:200), Immunocytochemistry (1:10-1:500), Imm... |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: PA1-16579 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
