Carbonic Anhydrase IX Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA116592 | 100 µL | 742,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Suggested positive control: antigen standard for CA9 (transient overexpression lysate), Renal carcinoma. Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ChIP, EL, FC, ICC, IHC, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | A synthetic peptide derived from a C-terminal sequence of the human CA IX. |
| Host | Rb |
| Genebank | CA9 |
| Isotype | IgG |
| Crossreactivity | Hu, Ms, Plant, Rt |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.02% sodium azide |
| Concentration | 1.0 mg/mL |
| Working Dilution | Gel Shift (Assay-Dependent), Western Blot (1-3 µg/mL), Immunocytochemistry (2-5 µg/mL), Immunohis... |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: PA1-16592 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
