LOX Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA116989 | 100 µL | 676,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This is a highly glycosylated protein and can exhibit bands at ~32 kDa, ~50 kDa and ~58 kDa representing the mature (secreted) form, the pro form and the glycosylated forms, respectively. Suggested positive control: MC3T3-E1 lysate. Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ICC, IHC, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Synthetic peptide made to an internal region of mouse LOX propeptide (residues 78-115). [UniProt# P28301] |
| Host | Rb |
| Genebank | LOX |
| Isotype | IgG |
| Crossreactivity | Hu, Ms, Primate, Pg, Rt |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Immunocytochemistry (5 µg/mL), Immunohistochemistry (Paraffin) (1:100-1:250), Western Blot (1:500... |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: PA1-16989 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
