IL-15 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA122494 | 25 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
PA1-22494 detects IL-15 in Mouse samples. IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheuma
Category | Antibody |
Supplier | ThermoFisher |
Application | N, WB |
Regulatory Status | RUO |
Immunogen | Recombinant full length protein (Mouse). Expressed in E. coli |
Host | Rb |
Genebank | IL15 |
Isotype | IgG |
Crossreactivity | Ms |
Clonality | Pab |
Format | Liquid; PBS; , with 0.1% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Western Blot (1:500), Neutralization (Assay-dependent) |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: PA1-22494 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |