IFN gamma Polyclonal Antibody

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Product Description

PA1-24782 will not react with human. The Neutralization Dose 50 (ND50) for anti-rat IFNG is approximately 0.08 to 0.2 µg/mL in the presence of 2.5 ng/mL of recombinant rat IFNG, measuring the protection of mouse L-929 cells from the lytic effect of the virus. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamm