c-Met Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA128026 | 25 µg | 678,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, IHC, N, WB |
Regulatory Status | RUO |
Immunogen | purified recombinant human hepatocyte growth factor receptor extracellular domain expressed in mouse NSO cells |
Host | Gt |
Genebank | MET |
Isotype | IgG |
Crossreactivity | Hu |
Clonality | Pab |
Format | Liquid; PBS; , with no preservative |
Concentration | 0.1 mg/mL |
Working Dilution | Western Blot (0.1-0.2 µg/mL), Neutralization (0.5-2 µg/mL), Immunohistochemistry (5-15 µg/mL), Fl... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: PA1-28026 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |