IDO Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA140279 | 100 µg | 744,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
PA1-40279 detects Indoleamine 2,3-dioxygenase from human samples. PA1-40279 has been successfully used in ELISA, flow cytometry, immunohistochemistry (paraffin), Western blot, and immunofluorescence applications. A typical starting dilution is 1:50. For Flow cytometry, it is recommended that the polyclonal antibody is used in combination with fixing and permeabilization. The PA1-40279 imunogen is recombinant IDO. IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, FC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Recombinant IDO. |
Host | Sh |
Genebank | IDO1 |
Isotype | IgG |
Crossreactivity | Hu |
Clonality | Pab |
Format | Liquid; PBS; , with 0.1% BSA and 0.02% sodium azide |
Concentration | 0.1 mg/mL |
Working Dilution | Flow Cytometry (1:50), Immunohistochemistry (Paraffin) (1:50), ELISA (1:50), Western Blot (1:50) |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: PA1-40279 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |