TRPA1 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| PA146159 | 100 µL | 654,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The target sequence has 69% sequence homology with rat. Suggested positive control: human brain membrane fraction. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, FC, ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Synthetic peptide corresponding to the N-terminus (residues 1-100) of the human TRPA1 protein.[Swis-Prot #075762] |
| Host | Rb |
| Genebank | TRPA1 |
| Isotype | IgG |
| Crossreactivity | Gp, Hu, Ms, Rt, Zebrafish |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Immunohistochemistry (Paraffin) (1:100-1:250), Western Blot (2 µg/mL), Immunocytochemistry (1:200... |
| Purity | Antigen affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: PA1-46159 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
