PAX6 Polyclonal Antibody

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Product Description

PA1-801 detects PAX6 from human, mouse, rat, non-human primate and ovine samples. This antibody does not detect bovine PAX6 by Western blot. PA1-801 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures. By Western blot, this antibody detects a ~47 kDa protein representing PAX6. The PA1-801 immunogen is a synthetic peptide corresponding to residues C R(267) E E K L R N Q R R Q A S N T P S H I(285) of mouse PAX6. This sequence is completely conserved in humans, mice, frogs, and chickens. This peptide (Product # PEP-207) is available for use in neutralization and control experiments. This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene.