HDAC3 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA1862 | 100 µg | 656,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
PA1-862 detects histone deacetylase 3 (HDAC3) from canine, hamster, human and rat tissues and cells. PA1-862 has been successfully used in Western blot and ChIP procedures. By Western blot, this antibody detects an ~48 kDa protein representing HDAC3 from HeLa cell lysate. The PA1-862 immunogen is a synthetic peptide corresponding to residues C D(415) G D H D N D K E S D V E I(428) of human HDAC3. This immunizing peptide (Cat. # PEP-071) is available for use in neutralization and control experiments. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Synthetic peptide corresponding to residues C D(415) G D H D N D K E S D V E I(428) of human HDAC3. |
Host | Rb |
Genebank | HDAC3 |
Isotype | IgG |
Crossreactivity | Dg, Hm, Hu, Rt |
Clonality | Pab |
Format | Liquid; PBS; , with 1mg/mL BSA and 0.05% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (1:200), Immunohistochemistry (Paraffin) (1:50), Western Blot (2.0 µg/mL), Ch... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PA1-862 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |