TGF beta-1 Polyclonal Antibody

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Product Description

PA1-9574 detects TGFb1 in human, mouse and rat samples. PA1-9574 has been successfully used in Western blot, Immunohistochemistry, Immunocytochemistry, and ELISA procedures. By Western blot, PA1-9574 detects a 25 kDa protein representing TGFb1. PA1-9574 immunogen is a peptide based on mouse and human TGFb1 protein (RKPKVEQLSNMIVRS). Store 4c for 1 week and -20c for long term storage. TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many oth