CRP Polyclonal Antibody

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Product Description

PA1-9579 detects CRP in rat samples. May cross react with mouse, human and other mammalia samples. PA1-9579 has been successfully used in Western blot, ICC, IHC, and ELISA procedures. By Western blot, PA1-9579 detects a 23 kDa protein representing CRP. PA1-9579 immunogen is a synthetic peptide corresponding to amino acids 108-121 of rat CRP. CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits. Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa. CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance. Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation. CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a