MRE11 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA316527 | 50 µL | 684,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This Mre11 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections (PMID 21279473) Immunoprecipitation and Western Blot. In WB, a band can be seen at ~81 kDa. For ICC/IF, this antibody has been used with methanol-fixed IMR90 primary human fibroblasts. For IP, the suggested working dilution is 3 µL for immunoprecipitation of 3X10^6 cells. Co-IP application has been reported by Ching et al 2012 (PMID: 22190719). Suggested positive control: antigen standard for MRE11A (transient overexpression lysate), Hela whole cell extract, Hela whole cell lysate. MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, EL, FC, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Human Mre11 full length. |
Host | Rb |
Genebank | MRE11 |
Isotype | IgG |
Crossreactivity | Ck, Hm, Hu, Ms, Rt |
Clonality | Pab |
Format | Liquid; whole serum; , with 0.02% sodium azide |
Working Dilution | ELISA (Assay-Dependent), Proximity Ligation Assay (PLA) (Assay-Dependent), Flow Cytometry (Assay-... |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: PA3-16527 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |