Complement C9 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA5119048 | 200 µL | 468,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Recombinant protein Complement Component 9. The antigen corresponds to amino acid range 139-519 of the target protein. |
Host | Gp |
Genebank | C9 |
Isotype | IgG |
Crossreactivity | Rb |
Clonality | Pab |
Format | Liquid; PBS; , with 50% glycerol and 0.05% ProClin 300 |
Concentration | 500 µg/mL |
Working Dilution | Immunocytochemistry (5-20 µg/mL), Immunohistochemistry (Paraffin) (5-20 µg/mL), Western Blot (0.5... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: PA5-119048 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |