IL-1 beta Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA5119219 | 200 µL | 469,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory c
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Recombinant protein Interleukin 1 Beta. The antigen corresponds to amino acid range 118-268 of the target protein. |
Host | Gp |
Genebank | IL1B |
Isotype | IgG |
Crossreactivity | Rb |
Clonality | Pab |
Format | Liquid; PBS; , with 50% glycerol and 0.05% ProClin 300 |
Concentration | 500 µg/mL |
Working Dilution | Immunohistochemistry (Paraffin) (5-20 µg/mL), Western Blot (0.5-2 µg/mL), Immunocytochemistry (5-... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: PA5-119219 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |