IDH1 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
PA5142665 | 100 µg | 415,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
Category | Antibody |
Supplier | ThermoFisher |
Application | WB |
Regulatory Status | RUO |
Immunogen | Peptide with sequence C-EPGSRHVGLDIKGQN. |
Host | Gt |
Genebank | IDH1 |
Isotype | IgG |
Crossreactivity | Yeast |
Clonality | Pab |
Format | Liquid; TBS; pH 7.3, with 0.5% BSA and 0.02% sodium azide |
Concentration | 0.5 mg/mL |
Working Dilution | Western Blot (0.5 µg/mL) |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: PA5-142665 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |